An algorithm to predict the age at which premature ovarian insufficiency (POI) may develop after an estimated dose of radiation to the ovary

Methodology: charts for the age-related decline in ovarian reserve and the radiotherapy dose-response curves based on an LD50 of 2 Gray (Gy) for the human oocyte

Disclaimer: This tool does not take the effects of gonadotoxic treatment other than radiotherapy into account. Please consider any additional risk due to (for example) alkylating agent chemotherapy when counselling patients. The LD50 used is 2.0 Gy, which is more damaging than the 4.0 Gy reported in earlier studies; neither estimate has been extensively validated. The prediction tool is not to be used as a substitute for medical advice, diagnosis, or treatment of any health condition or problem. Users of the prediction tool should not rely on information provided by the prediction tool for their own health problems. Questions should be addressed to your own physician or other healthcare provider. Use of the prediction tool does not create an express or implied physician-patient relationship

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